November 23rd, 2020
Alzheimer's disease is the preeminent cause and commonest form of dementia. It is clinically characterized by a progressive descent in the cognitive function, which commences with deterioration in memory. The exact etiology and pathophysiologic mechanism of Alzheimer's disease is still not fully understood. However, it is hypothesized that, neuroinflammation plays a critical role in the pathogenesis of Alzheimer's disease. Periodontitis is common oral infection affiliated with gram negative, anaerobic bacteria, capable of orchestrating localized and systemic infections in the subject. Periodontitis is known to elicit a "low grade systemic inflammation" by release of pro-inflammatory cytokines into systemic circulation. This review elucidates the possible role of periodontitis in exacerbating Alzheimer's disease. Periodontitis may bear the potential to affect the onset and progression of Alzheimer's disease. Periodontitis shares the two important features of Alzheimer's disease namely oxidative damage and inflammation, which are exhibited in the brain pathology of Alzheimer's disease. Periodontitis can be treated and hence it is a modifiable risk factor for Alzheimer's disease.
By Abhijit N Gurav - PubMed.gov
Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
Researchers at the University of Toronto have found first evidence that neutrophil immune cell activity is the missing link connecting periodontal disease with heart disease, cancer, and other inflammatory conditions
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery. This month, a team of scientists and clinicians led by Dr. Michael Glogauer University of Toronto's Faculty of Dentistry say they've found the reason why -- and it's related to the body's own hyperactive immune response.
ORAL HEALTH KEY TO OVERALL HEALTH
The study's findings underscore the importance of oral health as a vital indicator of potential complications for other inflammatory conditions, as well as disease model outcomes
Dr. Glogauer also suggests that there is evidence that patients with periodontal disease may be much more likely to have negative outcomes with COVID-19.
The findings were published in October in the Journal of Dental Research. Please click here to read the entire article.
A Search for a new cancer treatment accidently leads to an astounding medical breakthrough in part of the human body that has never before been discovered.
Scientist in the Netherlands discover additional saliva glands that may revolutionize cancer treatment. CTV National news looks to Dr. Glogauer for his insights.